chrystee pharris dating - Non sedating antihistamine
Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).
Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.
Another advantage of the newer antihistamines is that they're available in time-release versions.
That means you can control your symptoms with only 1 or 2 doses each day compared with older medications, which usually require doses every 4 to 6 hours to maintain their effectiveness.
This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.
Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.
The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are more effective than newer, non-sedating antihistamines.